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Can I read Cold ischaemia time: Is too long really too bad? Studies using a porcine kidney ex-vivo reperfusion model on EtoBox?
Cold ischaemia time: Is too long really too bad? Studies using a porcine kidney ex-vivo reperfusion model by Hamaoui, Karim; Gowers, Sally; Sandhu, Bynvant; Cook, Terry; Boutelle, Martyn; Casanova-Rituerto, Daniel; Papalois, Vassilios is a Medicine article available to read on EtoBox.
What is Cold ischaemia time: Is too long really too bad? Studies using a porcine kidney ex-vivo reperfusion model about?
Introduction: Post-ischaemic hypothermic machine perfusion (HMP) may be beneficial in recovery of marginal kidney grafts. The full capacity of conventional HMP (with passive oxygenation) to recondition an organ has not been realised. We investigated whether HMP can ameliorate ischemic damage caused by extremely prolonged static cold storage (SCS). Methods: Porcine kidneys underwent 4-h (SCS4,n 1⁄4 4) or 52-h (SCS52,n 1⁄4 4) SCS, followed by 10 h of HMP and were then subjected to 2 h of isolated normothermic reperfusion (NRP). Results: There was a post-SCS graft weight loss in SCS52 vs SCS4 kidneys. SCS52 kidneys showed viable perfusion dynamics during HMP, with significantly shorter times to reach viable parameters vs SCS4 kidneys (p < 0.027). During NRP SCS52 kidneys demonstrated similar trends in perfusion dynamics, renal function, oxygen consumptions, lactate production, and tubular injury to SCS4 kidneys. Conclusion: Graft weight loss after SCS, reducing resistance to perfusion, may facilitate better HMP dynamics and graft reconditioning. Clinicians utilising HMP should be aware of this phenomenon when using HMP in kidneys exposed to extreme periods of SCS. HMP after an extende
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- Author
- Hamaoui, Karim; Gowers, Sally; Sandhu, Bynvant; Cook, Terry; Boutelle, Martyn; Casanova-Rituerto, Daniel; Papalois, Vassilios
- Publisher
- Elsevier ; Elsevier Limited; [Oxford]: Elsevier Ltd.; Elsevier BV (ISSN 2405-8572)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)