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Primary Amine‐Initiated Polymerizations of Alanine‐NCA and Sarcosine‐NCA by Hans R. Kricheldorf; Colin von Lossow; Gert Schwarz is a scholarly article available to read on EtoBox.

What is Primary Amine‐Initiated Polymerizations of Alanine‐NCA and Sarcosine‐NCA about?

## Abstract **Summary:** Sarcosine‐__N__‐carboxyanhydride (Sar‐NCA), L‐alanine‐NCA and D,L‐alanine‐NCA were polymerized with benzylamine as initiator in three different solvents: dichloromethane (CH~2~Cl~2~), 1,4‐dioxane and dimethylformamide (DMF). The isolated polyaminoacids were characterized by ^1^H NMR spectroscopy and MALDI‐TOF mass spectrometry. High conversions and degrees of polymerization $\overline {DP}$s close to the monomer‐initiator (M/I) ratios were found for all polypeptides. For polysarcosine which was soluble under the given reaction conditions a narrow monomodal frequency distribution was found. In contrast, a broad frequency distribution was observed, when L‐alanine NCA was polymerized in dioxane and DMF. These results were attributed to a partial precipitation of oligopeptides in the __β__‐sheet structure, which reduces the reactivity of endgroups for steric reasons. The polymerizations of D,L‐alanine‐NCA showed features in between the extremes of Sar‐NCA and L‐Ala‐NCA. Schematic illustration of the secondary structures formed in a primary amine initiated polymerization of L‐Ala‐NCA. imageSchematic illustration of the secondary structures formed in a primary am

Author

Hans R. Kricheldorf; Colin von Lossow; Gert Schwarz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1022-1352)

Published

2004

Language

EN