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This study investigates the HDAC inhibitory and anti-cancer activities of the curcumin derivative CU17 against human lung cancer A549 cells. CU17 demonstrated greater HDAC inhibitory activity compared to curcumin and induced cell cycle arrest and apoptosis in A549 cells, while showing less toxicity to non-cancer cells. Additionally, CU17 enhanced the effectiveness of the chemotherapeutic agent Gem, suggesting its potential as an adjuvant treatment for lung cancer.

Author

Aaina Rathore

Language

EN