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Activation and Regulation of Cytoplasmic Dynein by John T. Canty; Ahmet Yildiz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Activation and Regulation of Cytoplasmic Dynein about?

Cytoplasmic dynein is an AAA motor that drives the transport of many intracellular cargoes towards the minus end of microtubules (MTs). Previous in vitro studies characterized isolated dynein as an exceptionally weak motor that moves slowly and diffuses on an MT. Recent studies altered this view by demonstrating that dynein remains in an autoinhibited conformation on its own, and processive motility is activated when it forms a ternary complex with dynactin and a cargo adaptor. This complex assembles more efficiently in the presence of Lis1, providing an explanation for why Lis1 is a required cofactor for most cytoplasmic dynein-driven processes in cells. This review describes how dynein motility is activated and regulated by cargo adaptors and accessory proteins.

Who reads Activation and Regulation of Cytoplasmic Dynein?

Author

John T. Canty; Ahmet Yildiz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0968-0004)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)