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The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats by Hala O El Mesallamy; Nadia S Metwally; Mahmoud S Soliman; Kawkab A Ahmed; Mai M Abdel Moaty is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background/objective This study was designed to evaluate the potential chemopreventive activities of __Ginkgo biloba__ extract (EGb) and __Silybum marianum__ extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (NDEA) in rats. ## Methods Rats were divided into 6 groups. Group 1 served as normal control rats. Group 2 animals were intragastrically administrated NDEA at a dose of 10 mg/kg five times a week for 12 weeks to induce hepatocellular carcinoma (HCC). Groups 3 and 4 animals were pretreated with silymarin and EGb respectively. Groups 5 and 6 animals were posttreated with silymarin and EGb respectively. The investigated parameters in serum are alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) and vascular endothelial growth factor (VEGF). The investigated parameters in liver tissue are malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and comet assay parameters. ## Results In NDEA group, MDA level was elevated with subsequent decrease in GSH level and SOD, GPx and GR activities. In addition, NDEA group revealed a significan

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Author

Hala O El Mesallamy; Nadia S Metwally; Mahmoud S Soliman; Kawkab A Ahmed; Mai M Abdel Moaty

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1475-2867)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)