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The G~1~ phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification by Mary K Harrison; Arsene M Adon; Harold I Saavedra is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome amplification and aneuploidy suggests that oncogenes and altered tumor suppressors are a major source of genomic instability in tumors, and that they generate those abnormal processes to initiate and sustain tumorigenesis. We discuss how altered tumor suppressors and oncogenes utilize the cell cycle regulatory machinery to signal centrosome amplification and aneuploidy.

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Author

Mary K Harrison; Arsene M Adon; Harold I Saavedra

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1747-1028)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)