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Localization of collagen X in human fetal and juvenile articular cartilage and bone by A. G. Nerlich; T. Kirsch; I. Wiest; P. Betz; K. von der Mark is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Localization of collagen X in human fetal and juvenile articular cartilage and bone about?

The tissue localization was analysed of collagen X during human fetal and juvenile articular cartilage-bone metamorphosis. This unique collagen type was found in the hypertrophic cartilage zone peri- and extracellularly and in cartilage residues within bone trabeculae. In addition, occasionally a slight intracellular staining reaction was found in prehypertrophic proliferating chondrocytes and in chondrocytes surrounding vascular channels. A slight staining was also seen in the zone of periosteal ossification and occasionally at the transition zone of the perichondrium to resting cartilage. Our data provide evidence that the appearance of collagen X is mainly associated with cartilage hypertrophy, analogous to the reported tissue distribution of this collagen type in animals. In addition, we observed an increased and often "spotty" distribution of collagen X with increasing cartilage "degeneration" associated with the closure of the growth plate. In basal hypertrophic cartilage areas, a co-distribution of collagens II and X was found with very little and "spotty" collagen III. In juvenile cartilage areas around single hypertrophic chondrocytes, co-localization of collagens X and I

Who reads Localization of collagen X in human fetal and juvenile articular cartilage and bone?

Author

A. G. Nerlich; T. Kirsch; I. Wiest; P. Betz; K. von der Mark

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-119X)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)