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137 Standardization of flow cytometry in myelodysplastic syndromes: A report from an international consortium and the European LeukemiaNet Working Group by T.M. Westers; R. Ireland; W. Kern; C. Alhan; J.S. Balleisen; M.C. Béné; P. Bettelheim; K. Burbury; M. Cullen; J.A. Cutler; M.G. Della Porta; A.M. Drager; J. Feuillard; P. Font; U. Germing; D. Haase; U. Johansson; S. Kordasti; M.R. Loken; L. Malcovati; J.G. te Marvelde; S. Matarraz; T. Milne; B. Moshaver; G.J. Mufti; K. Ogata; A. Orfao; A. Porwit; K. Psarra; S.J. Richards; D. Subirá; V. Tindell; T. Vallespi; P. Valent; V.H. van der Velden; T.M. de Witte; D.A. Wells; F. Zettl; A.A. van de Loosdrecht is a Medicine article available to read on EtoBox.

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results were not biased by the age of patients. The most informative parameters for discrimination between MDS and non-MDS were percentage of CD34+myeloid cells and CD10+B-cells, and myeloid and monocytic maturation (Table ). Conclusions: With the number of patients studied, FCI seems a promising tool for differential diagnosis of thrombocytopenia. Despite the absence of megakaryocytic parameters to study, abnormalities in the myelo-monocytic compartment, and B-cell and myeloid precursors are useful to suspect MDS. Introduction of new software programs for quantitative measurements of deviations improves the objectivity of FCI analyses, but the initial selection of populations still comprises a subjective approach. Table 1 Abnormal SSC/CD45 Abnormal myeloid maturation Abnormal monocytic maturation CD10mature granulocytes 2% CD34+ myeloid cells Median number of abnormalities ITP (n = 7) 0 2 0 0 1 0 0.43 Non-MDS (n = 7

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Author

T.M. Westers; R. Ireland; W. Kern; C. Alhan; J.S. Balleisen; M.C. Béné; P. Bettelheim; K. Burbury; M. Cullen; J.A. Cutler; M.G. Della Porta; A.M. Drager; J. Feuillard; P. Font; U. Germing; D. Haase; U. Johansson; S. Kordasti; M.R. Loken; L. Malcovati; J.G. te Marvelde; S. Matarraz; T. Milne; B. Moshaver; G.J. Mufti; K. Ogata; A. Orfao; A. Porwit; K. Psarra; S.J. Richards; D. Subirá; V. Tindell; T. Vallespi; P. Valent; V.H. van der Velden; T.M. de Witte; D.A. Wells; F. Zettl; A.A. van de Loosdrecht

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)

Published

2011

Language

EN

Field

Medicine (Health Sciences)