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Assessment of Clam Ruditapes philippinarum as Heavy Metal Bioindicators Using NMR‐Based Metabolomics by Xiaoli Liu; Linbao Zhang; Liping You; Junbao Yu; Ming Cong; Qing Wang; Fei Li; Lianzhen Li; Jianmin Zhao; Chenghua Li; Huifeng Wu is a Environmental Science article available to read on EtoBox.

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## Abstract There are mainly distributed three pedigrees (White, Liangdao Red, and Zebra) of Manila clam __Ruditapes philippinarum__ in Yantai population along the Bohai marine and coast. However, the biological differences to environmental stressors have been ignored in toxicology studies, which could lead to the distortion of biological interpretations of toxicological effects induced by environmental contaminants. In this study, we applied a system biology approach, metabolomics to compare the metabolic profiles in digestive gland from three pedigrees of clam and characterize and compare the metabolic responses induced by mercury in clam digestive gland tissues to determine a sensitive pedigree of clam as a preferable bioindicator for metal pollution monitoring and toxicology research. The most abundant metabolites, respectively, included branched‐chain amino acids, alanine, and arginine in White samples, glutamate, dimethylglycine, and glycine in Zebra clams and acetylcholine, betaine, glucose, and glycogen in Liangdao Red clams. After 48 h exposure of 20 μg L^−1^ Hg^2+^, the metabolic profiles from the three pedigrees of clams showed differentially significant changes in alani

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Author

Xiaoli Liu; Linbao Zhang; Liping You; Junbao Yu; Ming Cong; Qing Wang; Fei Li; Lianzhen Li; Jianmin Zhao; Chenghua Li; Huifeng Wu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 1863-0650)

Published

2011

Language

EN

Field

Environmental Science (Physical Sciences)