Can I read Epstein-barr Virus in Patients with Polymorphic Reticulosis (Lethal Midline Granuloma) from China and Japan on EtoBox?

Epstein-barr Virus in Patients with Polymorphic Reticulosis (Lethal Midline Granuloma) from China and Japan by Kenji Mishima; Keisuke Horiuchi; Shizuo Kojya; Hiroomi Takahashi; Masahiko Ohsawa; Katsuyuki Aozasa is a Medicine article available to read on EtoBox.

What is Epstein-barr Virus in Patients with Polymorphic Reticulosis (Lethal Midline Granuloma) from China and Japan about?

## Background: Polymorphic reticulosis is one of several diseases constituting lethal midline granuloma (lmg). previous immunohistochemical studies suggested a t-cell nature of proliferating cells; the term nasal t-cell lymphoma (ntl-lmg) has since been used widely. the authors' previous study in asian countries showed the clustering of mongolian patients with ntl-lmg, but the frequency varied with geographic area; it was much higher in korea and southwest japan (okinawa) than in shanghai and honshu, japan. recently an etiologic role of epstein-barr virus (ebv) for the development of ntl-lmg has been postulated. ## Methods: In this study, the presence of ebv and human t-cell lymphocytic leukemia virus type 1 (htlv-1) genomes were examined in ntl-lmg patients from southwest japan (okinawa, 10 patients), another japanese district (honshu, 21 patients), and shanghai, china (5 patients). all of the tissues from different geographic sites were analyzed at one central location. ## Results: Immunohistochemistry showed that proliferating large cells were positive for cd43 and/or cd45ro, identical with reported ntl-lmg cases. polymerase chain reaction (pcr) revealed the presence of ebv geno

Who reads Epstein-barr Virus in Patients with Polymorphic Reticulosis (Lethal Midline Granuloma) from China and Japan?

Author

Kenji Mishima; Keisuke Horiuchi; Shizuo Kojya; Hiroomi Takahashi; Masahiko Ohsawa; Katsuyuki Aozasa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1994

Language

EN

Field

Medicine (Health Sciences)