Opening book details…
Can I read Drug-induced Symmetry Effects on Ventricular Repolarization Dynamics on EtoBox?
Drug-induced Symmetry Effects on Ventricular Repolarization Dynamics by Pablo Daniel Cruces; Alejandra Toscano; Francisco Javier Alvarado Rodríguez; Rebeca Romo-Vázquez; Pedro David Arini is a Medicine article available to read on EtoBox.
What is Drug-induced Symmetry Effects on Ventricular Repolarization Dynamics about?
The detection of proarrhythmic effects of many current drugs has prompted the search for complementary non-invasive markers of cardiotoxicity risk. Indices based on studies of cardiac vector dynamics have emerged. We use quaternions to quantify symmetry changes in cardiac vector velocity during ventricular repolarization, which could signal the arrhythmia risk. Principal component analysis is used to homogenize the information and reduce the space to three dimensions. A comparison with the ratio of normalized areas of the repolarization loop (T-wave) and two standard measurements was made: QT and T peak-end intervals. Assessment was conducted by comparing 52 healthy subjects with patients undergoing treatment with Sotalol: 7 recordings with Torsade de Pointes events and 15 without arrhythmic effects. Significant differences (p ¡ 5E-4) were found in both phases of repolarization in terms of absolute velocities and areas. The ratio between the maximums of each parameter in both halves of the T-wave showed a trend towards 1 in the proximity of an arrhythmic event. Angular velocity ratios reached a sensitivity/specificity pair of 100 (95%CI: 59–100)/90 (95%CI: 79–97) with an AUC of 98.
Who reads Drug-induced Symmetry Effects on Ventricular Repolarization Dynamics?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Pablo Daniel Cruces; Alejandra Toscano; Francisco Javier Alvarado Rodríguez; Rebeca Romo-Vázquez; Pedro David Arini
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Physical Sciences)