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Neurobehavioral Tests in Rat Models of Degenerative Brain Diseases by Yvonne K. Urbach; Felix J. Bode; Huu Phuc Nguyen; Olaf Riess; Stephan von Hörsten is a book available to read on EtoBox.

What is Neurobehavioral Tests in Rat Models of Degenerative Brain Diseases about?

Each translational approach in medical research forces the establishment of neurobehavioral screening systems, dedicated to fill the gap between postgenomic generation of state-of-the-art animal models (i.e. transgenic rats) on the one hand and their added value for really predictive experimental preclinical therapy on the other. Owing to these developments in the field, neuroscientists are frequently challenged by the task of detecting discrete behavioral differences in rats. Systematic, comprehensive phenotyping covers these needs and represents a central part of the process. In this chapter, we provide an overview on theoretical issues related to comprehensive neurobehavioral phenotyping of rats and propose specific classical procedures, protocols (similar to the SHIRPA approach in mice), as well as techniques for repeated, intraindividual phenotyping. Neurological testing of rats, motorfunctional screening using the accelerod approach, emotional screening using the social interaction test of anxiety, and testing of sensorimotoric gating functions by prepulse inhibition of the startle response are provided in more detail. This description is completed by an outlook on most recen

Author

Yvonne K. Urbach; Felix J. Bode; Huu Phuc Nguyen; Olaf Riess; Stephan von Hörsten

Publisher

Humana Press, Springer Science+Business Media

Published

2009

Language

EN

ISBN

9781603273886

Subjects

Science, Chemistry, Biology