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MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours by Malgorzata Bulkowska; Agata Rybicka; Kerem Mert Senses; Katarzyna Ulewicz; Katarzyna Witt; Joanna Szymanska; Bartlomiej Taciak; Robert Klopfleisch; Eva Hellmén; Izabella Dolka; Ali O. Gure; Joanna Mucha; Mariusz Mikow; Slawomir Gizinski; Magdalena Krol is a Medicine article available to read on EtoBox.
What is MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours about?
## Background: Micrornas may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. several common oncogenic micrornas have been found for canine mammary cancer and human breast cancer. on account of this, large-scale profiling of microrna expression in canine mammary cancer seems to be important for both dogs and humans. ## Methods: Expression profiles of 317 micrornas in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases) and in 25 control samples were evaluated. the profiling was performed using microarrays. significance analysis of microarrays test was applied in the analysis of microarray data (both unsupervised and supervised data analyses were performed). validation of the obtained results was performed using real-time qpcr. subsequently, predicted targets for the micrornas were searched for in mirbase. ## Results: Results of the unsupervised analysis indicate that the primary factor separating the samples is the metastasis status. predicted targets for micrornas differentially expressed in the meta
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- Author
- Malgorzata Bulkowska; Agata Rybicka; Kerem Mert Senses; Katarzyna Ulewicz; Katarzyna Witt; Joanna Szymanska; Bartlomiej Taciak; Robert Klopfleisch; Eva Hellmén; Izabella Dolka; Ali O. Gure; Joanna Mucha; Mariusz Mikow; Slawomir Gizinski; Magdalena Krol
- Publisher
- Springer Science and Business Media LLC
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)