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Can I read A Novel Diblock of Copolymer of (Monomethoxy Poly [Ethylene Glycol]-oleate) with a Small Hydrophobic Fraction to Make Stable Micelles/polymersomes for Curcumin Delivery to Cancer Cells on EtoBox?
A Novel Diblock of Copolymer of (Monomethoxy Poly [Ethylene Glycol]-oleate) with a Small Hydrophobic Fraction to Make Stable Micelles/polymersomes for Curcumin Delivery to Cancer Cells by Vahid Erfani-Moghadam; Alireza Nomani; Mina Zamani; Yaghoub Yazdani; Farhood Najafi; Majid Sadeghizadeh is a Materials Science article available to read on EtoBox.
What is A Novel Diblock of Copolymer of (Monomethoxy Poly [Ethylene Glycol]-oleate) with a Small Hydrophobic Fraction to Make Stable Micelles/polymersomes for Curcumin Delivery to Cancer Cells about?
Curcumin is a potent natural anticancer agent, but its effectiveness is limited by properties such as very low solubility, high rate of degradation, and low rate of absorption of its hydrophobic molecules in vivo. To date, various nanocarriers have been used to improve the bioavailability of this hydrophobic biomaterial. This study investigates the encapsulation of curcumin in a novel nanostructure of monomethoxy poly(ethylene glycol)-oleate (mPEG-OA) and its anticancer effect. Tests were done to determine the critical micelle concentration (CMC), encapsulation efficiency, drug-loading efficiency, and cytotoxicity (against U87MG brain carcinoma cells and HFSF-PI3 cells as normal human fibroblasts) of some nanodevice preparations. The results of fluorescence microscopy and cell-cycle analyses indicated that the in vitro bioavailability of the encapsulated curcumin was significantly greater than that of free curcumin. Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 μM and 24 μM, respectively. The Annexin-V-FLUOS assay was used to quantify the apoptotic effect of the prepare
Who reads A Novel Diblock of Copolymer of (Monomethoxy Poly [Ethylene Glycol]-oleate) with a Small Hydrophobic Fraction to Make Stable Micelles/polymersomes for Curcumin Delivery to Cancer Cells?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Vahid Erfani-Moghadam; Alireza Nomani; Mina Zamani; Yaghoub Yazdani; Farhood Najafi; Majid Sadeghizadeh
- Publisher
- Informa UK Limited
- Published
- 2014
- Language
- EN
- Field
- Materials Science (Physical Sciences)