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An investigation of the parameters influencing the bioadhesive properties of Myverol 18–99/water gels by P.B. Geraghty; D. Attwood; J.H. Collett; H. Sharma; Y. Dandiker is a Engineering article available to read on EtoBox.

What is An investigation of the parameters influencing the bioadhesive properties of Myverol 18–99/water gels about?

An in vitro assessment was undertaken of the parameters influencing the bioadhesive strength of lyotropic liquid crystalline gels formed by the monoglyceride blend Myverol 18-99 and water. The gels were found to bind more strongly to a dry Perspex surface than to moist mucosal tissue and were shown to be weaker bioadhesives than Carbopol 934P and sodium alginate. The works of adhesion and forces of detachment were independent of contact time, were reduced by the presence of surface water and increased with an increase in the compression force, suggesting that interpenetration was not the mechanism of bioadhesion. The bioadhesion of Myverol 1%99/water gels appeared to be due to secondary chemical bonds, such as van der Waals forces, but was limited by their cohesive strength. An in vivo gel retention assessment by gamma scintigraphy showed that the gels were retained within the vaginal cavity for a period of at least 6 h.

Who reads An investigation of the parameters influencing the bioadhesive properties of Myverol 18–99/water gels?

Author

P.B. Geraghty; D. Attwood; J.H. Collett; H. Sharma; Y. Dandiker

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

1997

Language

EN

Field

Engineering (Physical Sciences)