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Characterization of the Immunomodulatory Properties of Alveolar Bone-derived Mesenchymal Stem Cells by Cao, Chen; Tarlé, Susan; Kaigler, Darnell is a Medicine article available to read on EtoBox.

What is Characterization of the Immunomodulatory Properties of Alveolar Bone-derived Mesenchymal Stem Cells about?

## Background Recently, mesenchymal stem cells (MSCs) have been shown to have immunomodulatory properties which hold promise for their clinical use to treat inflammatory conditions. Relative to bone marrow-derived MSCs (BMSCs), which are typically isolated from the iliac crest, we have recently demonstrated that MSCs can be predictably isolated from the alveolar bone (aBMSCs) by less invasive means. As such, the aim of this study was to characterize the immunomodulatory properties of aBMSCs relative to BMSCs. ## Methods aBMSCs isolated from the human alveolar bone and BMSCs isolated from the human bone marrow of the iliac crest were cultured in the same conditions. Cytokine arrays and enzyme-linked immunosorbent assays (ELISA) of a conditioned medium were used to evaluate differences in the secretion of cytokines. In different functional assays, aBMSCs and BMSCs were cocultured with different types of immune cells including THP-1 monocytes, macrophages, and peripheral blood mononuclear cells (PBMCs) to evaluate their effects on important immune cell functions including proliferation, differentiation, and activation. ## Results The protein arrays identified interleukin (IL)-6 and mo

Who reads Characterization of the Immunomodulatory Properties of Alveolar Bone-derived Mesenchymal Stem Cells?

Author

Cao, Chen; Tarlé, Susan; Kaigler, Darnell

Publisher

BioMed Central; Springer (Biomed Central Ltd.); Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1757-6512)

Published

2020

Language

EN

Field

Medicine (Health Sciences)