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Synthesis of Novel Halogenated Cryptolepine Analogues by Srinivas Reddy Gouni; S. Carrington; C. W. Wright is a Chemistry article available to read on EtoBox.

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## Abstract magnified image Cryptolepine (5‐__N__‐methyl‐10‐__H__‐indolo[3,2‐__b__]quinoline) is an indoloquinoline alkaloid present in the roots of __Cryptolepis Sanguinolenta__. In its hydrochloride form the alkaloid presents a number of bioactivities. The alkaloid also has cytotoxic properties that are likely to be due to its abilities to intercalate into DNA and inhibit the enzyme topoisomerase II, as well as the synthesis of DNA. In this research project five novel analogues of cryptolepine were chosen for synthesis.

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Author

Srinivas Reddy Gouni; S. Carrington; C. W. Wright

Publisher

Journal of Heterocyclic Chemistry; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 0022-152X)

Published

2006

Language

EN

Field

Chemistry (Physical Sciences)