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Comparison of genomic abnormalities between BRCAX and sporadic breast cancers studied by comparative genomic hybridization by Jacek Gronwald; Anna Jauch; Cezary Cybulski; Brigitte Schoell; Barbara Böhm‐Steuer; Marcin Lener; Ewa Grabowska; Bohdan Górski; Anna Jakubowska; Wenancjusz Domagała; Maria Chosia; Rodney J. Scott; Jan Lubiński is a Medicine article available to read on EtoBox.

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## Abstract Very little is known about the chromosomal regions harbouring genes involved in initiation and progression of __BRCAX__‐associated breast cancers. We applied comparative genomic hybridization (CGH) to identify the most frequent genomic imbalances in 18 __BRCAX__ hereditary breast cancers and compared them to chromosomal aberrations detected in a group of 27 sporadic breast cancers. The aberrations observed most frequently in __BRCAX__ tumours were gains of 8q (83%), 19q (67%), 19p (61%), 20q (61%), 1q (56%), 17q (56%) and losses of 8p (56%), 11q (44%) and 13q (33%). The sporadic cases most frequently showed gains of 1q (67%), 8q (48%), 17q (37%), 16p (33%), 19q (33%) and losses of 11q (26%), 8p (22%) and 16q (19%). Losses of 8p and gains 8q, 19 as well as gains of 20q (with respect to ductal tumours only) were detected significantly more often in __BRCAX__ than in sporadic breast cancers. Analysis of 8p‐losses and 8q‐gains showed that these aberrations are early events in the tumorigenesis of __BRCAX__ tumors. The findings of this report indicate similarities between __BRCAX__ and __BRCA2__ tumours, possibly suggesting a common pathway of disease. These findings need co

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Author

Jacek Gronwald; Anna Jauch; Cezary Cybulski; Brigitte Schoell; Barbara Böhm‐Steuer; Marcin Lener; Ewa Grabowska; Bohdan Górski; Anna Jakubowska; Wenancjusz Domagała; Maria Chosia; Rodney J. Scott; Jan Lubiński

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)