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C(sp3)–H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions by Wen-Ting Wei; Wei-Wei Ying; Wen-Ming Zhu; Zhanghua Gao; Hongze Liang is a Chemistry article available to read on EtoBox.

What is C(sp3)–H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions about?

A C(sp3)–H peroxidation of 3-substituted indolin-2-ones through radical coupling reaction has been developed under metal-free conditions. Using tert-butyl hydroperoxide both as an oxidant and as a peroxidation reagent to couple with the C(sp3)–H bonds of 3-substituted indolin-2-ones can form a new C–O bond without using any additives. This simple strategy provides a green and efficient approach to 3-peroxyindolin-2-ones in moderate to excellent yields. The resulting 3-peroxyindolin-2-ones could be further transformed into 3-hydroxy­indolin-2-ones.

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Author

Wen-Ting Wei; Wei-Wei Ying; Wen-Ming Zhu; Zhanghua Gao; Hongze Liang

Publisher

Georg Thieme Verlag KG

Published

2017

Language

EN

Field

Chemistry (Physical Sciences)