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Interlaboratory Bias of Albuminuria and Proteinuria in Hypertensive Pregnancy by Benoit Denhez; Li Wang; Julie Moreau; Jean Dubé; Anne-Marie Côté is a Medicine article available to read on EtoBox.

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## Background: Measurement of proteinuria in women with hypertensive disorders of pregnancy is of major importance in the diagnosis and management of preeclampsia. urinary protein/creatinine ratio, which is commonly used to detect kidney damage in preeclampsia, suffers from important analytical limitations, including poor harmonization of results between laboratories. adoption of albuminuria could help reduce interlaboratory bias, since methods used to quantify it are better harmonized. ## Methods: A total of 27 urinary samples collected from hypertensive women evaluated for preeclampsia were sent to four different clinical laboratories in canada. urinary proteins and albumin as well as urinary creatinine were measured in duplicates in one batch to calculate protein/creatinine (pcr) and albumin/creatinine (acr) ratio. statistical analyses were done to evaluate interlaboratory variability of urinary proteins and urinary albumin. ## Results: Interlaboratory bias for urinary proteins ranged from 64.7% at low concentration to 3.9% at higher concentrations. in contrast, urinary albumin interlaboratory bias ranged from 29.2% to 4% from low to high concentrations. coefficient of variation

Who reads Interlaboratory Bias of Albuminuria and Proteinuria in Hypertensive Pregnancy?

Author

Benoit Denhez; Li Wang; Julie Moreau; Jean Dubé; Anne-Marie Côté

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2020

Language

EN

Field

Medicine (Health Sciences)