Can I read BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat on EtoBox?

BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat by G. D. Graham; J. Zhong; O. A. C. Petroff; R. T. Constable; J. W. Prichard; J. C. Gore is a scholarly article available to read on EtoBox.

What is BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat about?

## Abstract To evaluate MRI methods for estimating cerebrovascular reserve, we computed changes in the R~2~\* and R~2~, transverse relaxation rate and apparent diffusion coefficient (ADC) at 2.0 Tesla in five rats after administration of 30 mg of acetazolamide and in four rats during inhalation of 20% carbon dioxide gas. Significant decreases in R~2~\*, corresponding to increases in gradient echo MRI signals, occurred in both the acetazolamide (average change −8.3%, __P__ = 0.005) and the carbon dioxide (−2.7%, __P__ = 0.009) treated animals. The computed values for R~2~ and ADC were unchanged. The magnitude of the gradient echo MRI changes observed should permit anatomic mapping of blood flow reactivity patterns in normal human subjects and in patients at risk for cerebrovascular disease.

Author

G. D. Graham; J. Zhong; O. A. C. Petroff; R. T. Constable; J. W. Prichard; J. C. Gore

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1994

Language

EN

ISBN

9781910310519