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In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica by Saw Bawm; Hideyuki Matsuura; Ahmed Elkhateeb; Kensuke Nabeta; Subeki; Nariaki Nonaka; Yuzaburo Oku; Ken Katakura is a Immunology and Microbiology article available to read on EtoBox.
What is In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica about?
The medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae) is widely distributed throughout Asia where its bitter fruits have been used in traditional medicine for various ailments. Fifteen C-20 quassinoids were isolated from the fruits of B. javanica and examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Bruceine A, bruceantinol, bruceine C, brusatol, and bruceine B showed strong antitrypanosomal activities with IC 50 values in the range of 2.9-17.8 nM, which compared well with the standard trypanocidal drugs diminazene aceturate (IC 50 = 8.8 nM) and suramin (IC 50 = 43.2 nM). However, dehydrobruceine A, dehydrobruceine B, and dehydrobrusatol were about 2100, 900, and 1200 times less active, respectively, than bruceine A, bruceine B, and brusatol. The relationship of the structure and antitrypanosomal activity of these quassinoid compounds suggested that the presence of a diosphenol moiety in ring A and the nature of the C-15 side chain are important for their activities against T. evansi. This is the first report on the antitrypanosomal activity of isolated quassinoids.
Who reads In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Saw Bawm; Hideyuki Matsuura; Ahmed Elkhateeb; Kensuke Nabeta; Subeki; Nariaki Nonaka; Yuzaburo Oku; Ken Katakura
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)
- Published
- 2008
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)