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Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson's disease heterogeneity by Emily J. Hill; C. Grant Mangleburg; Isabel Alfradique-Dunham; Brittany Ripperger; Amanda Stillwell; Hiba Saade; Sindhu Rao; Oluwafunmiso Fagbongbe; Rainer von Coelln; Arjun Tarakad; Christine Hunter; Robert J. Dawe; Joseph Jankovic; Lisa M. Shulman; Aron S. Buchman; Joshua M. Shulman is a Medicine article available to read on EtoBox.
What is Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson's disease heterogeneity about?
## Introduction: Emerging technologies show promise for enhanced characterization of parkinson's disease (pd) motor manifestations. we evaluated quantitative mobility measures from a wearable device compared to the conventional motor assessment, the movement disorders society-unified pd rating scale part iii (motor mds-updrs). ## Methods: We evaluated 176 pd subjects (mean age 65, 65% male, 66% h&y stage 2) during routine clinic visits using the motor mds-updrs and a 10-min motor protocol with a body-fixed sensor (dynaport mt, mcroberts bv), including the 32-ft walk, timed up and go (tug), and standing posture with eyes closed. regression models examined 12 quantitative mobility measures for associations with (i) motor mds-updrs, (ii) motor subtype (tremor dominant vs. postural instability/gait difficulty), (iii) montreal cognitive assessment (moca), and (iv) physical functioning disability (promis-29). all analyses included age, gender, and disease duration as covariates. models iii-iv were secondarily adjusted for motor mds-updrs. ## Results: Quantitative mobility measures from gait, tug transitions, turning, and posture were significantly associated with motor mds-updrs (7 of 12
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- Author
- Emily J. Hill; C. Grant Mangleburg; Isabel Alfradique-Dunham; Brittany Ripperger; Amanda Stillwell; Hiba Saade; Sindhu Rao; Oluwafunmiso Fagbongbe; Rainer von Coelln; Arjun Tarakad; Christine Hunter; Robert J. Dawe; Joseph Jankovic; Lisa M. Shulman; Aron S. Buchman; Joshua M. Shulman
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)