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Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort by Ya-Wen Lu; Chun-Chin Chang; Ruey-Hsing Chou; Wei-Ju Lee; Liang-Kung Chen; Po-Hsun Huang; Shing-Jong Lin is a scholarly article available to read on EtoBox.

What is Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort about?

## Background Frailty is a common geriatric syndrome related to multiple adverse outcomes. Sex differences in its prevalence and impact on mortality remain incompletely understood. ## Methods This study was conducted with data from the I-Lan Longitudinal Aging Study, in which community-dwelling subjects aged > 50 years without coronary artery disease or diabetes were enrolled. Sex disparities in phenotypically defined frailty and sex–morality predictor interactions were evaluated. Sex- and frailty-stratified analyses of mortality were performed. ## Results The sample comprised 1371 subjects (51.4% women, median age 61 years). The median follow-up period was 6.3 (interquartile range, 5.8–7.0) years. The frailty prevalence did not differ between men (5.3%) and women (5.8%). Frail individuals were older and less educated and had poorer renal function than did non-frail individuals. Body composition trends differed between sexes, regardless of frailty. Relative to non-frail men, frail men had significantly lower body mass indices (BMIs; 24.5 vs. 23.4 kg/m^2^, __p__ = 0.04) and relative appendicular skeletal muscle masses (7.87 vs. 7.05 kg/m^2^, __p__ < 0.001). Frail women had significa

Author

Ya-Wen Lu; Chun-Chin Chang; Ruey-Hsing Chou; Wei-Ju Lee; Liang-Kung Chen; Po-Hsun Huang; Shing-Jong Lin

Publisher

BioMed Central

Published

2024

Language

EN