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Diminished IFN-γ and IL-10 and elevated Foxp3 mRNA expression in the cervix are associated with CIN 2 or 3 by Mark E. Scott; Yifei Ma; Lili Kuzmich; Anna-Barbara Moscicki is a Medicine article available to read on EtoBox.

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## Abstract Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understood to be important modulators of cellular immunity. Using quantitative RT‐PCR, we measured, in cross‐sectional design, the cervical mRNA expression of IFN‐γ, IL‐10, and IL‐12, as well as the Treg transcription factor Forkhead box P3 (Foxp3), in a cohort of young women representing CIN 1, 2, and 3, as well as benign histology. Higher levels of IFN‐γ and IL‐10 were significantly (__p__ ≤ 0.05) associated with decreased odds of having high‐grade cervical disease (CIN 2 or 3) in multivariate logistic regression models. In contrast, higher levels of mucosal Foxp3 expression were associated with increased odds of having CIN 2 or 3 (__p__ = 0.004). In a multivariate model including cervical infection with HPV16 and/or another high‐risk HPV type, Foxp3 remained higher in the CIN 2/3 group, but the difference was notably less significant (__p__ = 0.05). These finding

Who reads Diminished IFN-γ and IL-10 and elevated Foxp3 mRNA expression in the cervix are associated with CIN 2 or 3?

Author

Mark E. Scott; Yifei Ma; Lili Kuzmich; Anna-Barbara Moscicki

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN

Field

Medicine (Health Sciences)