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Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints by Daniel R. Croft; Peter Dull; Derek Davies; David G. Jackson; Peter McIntyre; Ijsbrand M. Kramer is a Immunology and Microbiology article available to read on EtoBox.

What is Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints about?

## Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints CD44 is a broadly expressed cell surface glycoprotein which is the major cell surface receptor for the glycosaminoglycan, hyaluronan. In humans, alternative splicing of up to 9 variant exons (v2-v10) into CD44 mRNA, together with posttranslational modification via glycosylation and chondroitin sulfate attachment has the potential of generating a large number of CD44 isoforms. Insertion of these various exons has the potential to change the functional capacities of the molecule and has implications in disease. We have analyzed CD44 splice variant expression in cultured VCAM-1-positive synovial fibroblasts isolated from patients with osteo-or rheumatoid arthritis and from normal synovium. Rheumatoid and osteoarthritic tissue express CD44 splice variants at the cell surface level. At the mRNA level exons v3, v6, v7, v8, v9 and v10 were detected in different splicing combinations. Rheumatoid tissue showed high expression, osteoarthritic tissues showed great variation. In contrast, non-inflamed tissue showed no splicing events. Our results indicate that the nature of CD44 splice variant expression may be

Who reads Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints?

Author

Daniel R. Croft; Peter Dull; Derek Davies; David G. Jackson; Peter McIntyre; Ijsbrand M. Kramer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)