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Can I read Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARα fusion gene formation, relapsing as acute promyelocytic leukaemia M3 on EtoBox?
Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARα fusion gene formation, relapsing as acute promyelocytic leukaemia M3 by Andres Virchis; Edwin Massey; Tina Butler; Prema Devaraj; Faith Wright; Lorna Secker‐Walker; H. Grant Prentice; Atul Mehta is a Medicine article available to read on EtoBox.
What is Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARα fusion gene formation, relapsing as acute promyelocytic leukaemia M3 about?
Demonstration of either the translocation t(15;17)(q22;q21) or the fusion of __PML__ and __RARα__ genes is regarded as diagnostic for acute myeloid leukaemia (AML) of FAB type M3, but has occasionally been seen in other FAB types. We present two such cases. Case 1 presented with FAB type M6 and a complex karyotype involving chromosomes 1, 2, 11 and 17. Bone marrow relapse of FAB type M3 followed autologous bone marrow transplantation. Subsequent marrow dysplasia and an M6 relapse were accompanied by a new cytogenetic clone involving chromosomes X, 2, 4, 6, 7 and 16. Fluorescence __in situ__ hybridization (FISH) of metaphase chromosomes at diagnosis showed insertion of material from chromosome 17 into a ‘normal’ 15 with juxtaposition of __PML and RARα__. Case 2 presented as AML M4 and relapsed as M3. Cytogenetic analysis at diagnosis and in relapse showed 46,XY,t(15;17)(q22;q11),del(16)(q22). FISH analysis showed this to be a three‐way translocation involving chromosomes 15, 16 and 17 again with juxtaposition of __PML and RARα__. Reverse transcription‐polymerase chain reaction (RT‐PCR) revealed __PML/RARα__ fusion at diagnosis, in remission and in first relapse. These examples stren
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- Author
- Andres Virchis; Edwin Massey; Tina Butler; Prema Devaraj; Faith Wright; Lorna Secker‐Walker; H. Grant Prentice; Atul Mehta
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)