About this Biochemistry, Genetics and Molecular Biology article
Combretoxazolones: Synthesis, Cytotoxicity and Antitumor Activity by Nguyen-Hai Nam; Yong Kim; Young-Jae You; Dong-Ho Hong; Hwan-Mook Kim; Byung-Zun Ahn is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nguyen-Hai Nam; Yong Kim; Young-Jae You; Dong-Ho Hong; Hwan-Mook Kim; Byung-Zun Ahn
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)