Can I read Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives on EtoBox?

Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives by Dao Duc Thien; Nguyen Thanh Tam; Dinh Gia Thien; Nguyen Thi Hoang Anh; Tran Van Sung is a scholarly article available to read on EtoBox.

What is Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives about?

## 10-15 Fourteen ursolic acid derivatives, among them four novel compounds, were synthesized by modification either at the C-3, C-28 or both positions. The cytotoxic activity of the obtained derivatives was evaluated against the four human cancer cell lines KB (human mouth epidermal carcinoma), HepG2 (human hepatocellular carcinoma), MCF7 (human breast carcinoma) and Lu (human lung carcinoma). As the result, compounds 7and 8were from two to three times more active than ursolic acid on all four tested cell lines. This is the first report on cytotoxic effects of the synthetized ursolic acid derivatives 4, 8, and .

Author

Dao Duc Thien; Nguyen Thanh Tam; Dinh Gia Thien; Nguyen Thi Hoang Anh; Tran Van Sung

Publisher

Walter de Gruyter GmbH

Published

2013

Language

EN