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Synthesis of a ^11^C‐labelled taxane derivative by [1‐^11^C]acetylation by P. Mäding; J. Zessin; U. Pleiß; F. Füchtner; F. Wüst is a Medicine article available to read on EtoBox.

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## Abstract The ^11^C‐labelling of the taxane derivative BAY 59‐8862 (**1**), a potent anticancer drug, was carried out as a module‐assisted automated multi‐step synthesis procedure. The radiotracer **[^11^C]1** was synthesized by reacting [1‐^11^C]acetyl chloride (**6**) with the lithium salt of the secondary hydroxy group of precursor **3** followed by deprotection. After HPLC purification of the final product **[^11^C]1**, its solid‐phase extraction, formulation and sterile filtration, the decay‐corrected radiochemical yield of **[^11^C]1** was in the range between 12 and 23% (related to [^11^C]CO~2~; __n__=10). The total synthesis time was about 54 min after EOB. The radiochemical purity of **[^11^C]1** was greater than 96% and the chemical purity exceeded 80%. The specific radioactivity was 16.8±4.7 GBq/μmol (__n__=10) at EOS starting from 80 GBq of [^11^C]CO~2~. Copyright © 2006 John Wiley & Sons, Ltd.

Who reads Synthesis of a ^11^C‐labelled taxane derivative by [1‐^11^C]acetylation?

Author

P. Mäding; J. Zessin; U. Pleiß; F. Füchtner; F. Wüst

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

2006

Language

EN

Field

Medicine (Life Sciences)