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The Impact of Age-related Sub-chronic Exposure to Chlorpyrifos on Metabolic Indexes in Male Rats by Samarghandian, Saeed; Foadoddin, Moshen; Zardast, Mahmoud; Mehrpour, Omid; Sadighara, Parisa; Roshanravan, Babak; Farkhondeh, Tahereh is a Environmental Science article available to read on EtoBox.
What is The Impact of Age-related Sub-chronic Exposure to Chlorpyrifos on Metabolic Indexes in Male Rats about?
Chlorpyrifos (CPF), an organophosphorus pesticide (OP), has been implicated in metabolic diseases; however, the data are controversial. Rising age has been found as a main risk factor for metabolic diseases, and it has been proposed that advanced age increases susceptibility to the toxic effects of OPs. Therefore, this investigation aimed to evaluate the impact of CPF on hyperglycemia, hypercholesterolemia, and inflammation in animals with different ages. CPF (5 mg/kg) for 45 consecutive days was administered orally to male Wistar rats with different ages including 2-, 10-, and 20-month-old. The results indicated an increase in glucose and inflammatory indices, and also lipid profile was changed in the serum of aged animals in comparison with the 2-month-old animals. CPF administration amplified these parameters in the 20-month-old rats in comparison with that of aged-matched controls. The histopathological examination also indicated that CPF caused slight to moderate changes in the liver of 2-, 10-, and 20-month-old animals. Cholestasis was also observed in the CPF-administrated 20-month-old rats. In conclusion, aging may increase the susceptibility to CPF-induced metabolic distur
Who reads The Impact of Age-related Sub-chronic Exposure to Chlorpyrifos on Metabolic Indexes in Male Rats?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Samarghandian, Saeed; Foadoddin, Moshen; Zardast, Mahmoud; Mehrpour, Omid; Sadighara, Parisa; Roshanravan, Babak; Farkhondeh, Tahereh
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Publons; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0944-1344)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)