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## Abstract In describing the Na^+^ channel‐gating kinetics, it is generally believed the Hodgkin–Huxley model is inadequate and other types of Markovian models are more appropriate. In this paper, we perform detailed kinetic analyses to find out whether the Hodgkin–Huxley model is really unacceptable. Specifically, we consider two models for the analyses: A five‐state Markovian model that allows inactivation to take place before opening and a Hodgkin–Huxley eight‐state model. The criteria used to check the goodness of the two models are (a) Akaike's information criterion; (b) χ^2^ tests on the waiting‐time, open‐time, and closed‐time distributions, and the number of openings per record; and (c) comparison between all latency distributions and the probability of the open state predicted from the two models. In order to do this, we first develop a method of constructing probability density histograms of a specified event (e.g., waiting time, closed time, open time, number of openings per patch) from the multichannel patch‐clamp recordings. The goodness of our method is checked by simulating multichannel patch recordings using a multinomial random number generator. Our kinetic analys

Who reads The Hodgkin–Huxley Na^+^ channel model versus the five‐state Markovian model?

Author

Teresa Ree Chay

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1991

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)