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Biodistribution and accumulation of intravenously administered carbon nanotubes in mice probed by Raman spectroscopy and fluorescent labeling by Bin Kang; Decai Yu; Yaodong Dai; Shuquan Chang; Da Chen; Yitao Ding is a Materials Science article available to read on EtoBox.

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The circulation, distribution and accumulation of intravenously administered singlewalled carbon nanotubes (SWCNTs) in mice have been investigated by using the Raman spectroscopy and fluorescent labeling. The SWCNTs exhibited a rapid blood clearance with a half-life time of 3-4 h. However, rapid uptake and high levels of SWCNTs were observed in liver of mice. These SWCNTs accumulated in liver and were hard to excrete. The SWCNTs in liver led to pathological changes of liver, including injury of macrophages, cellular swelling, unspecific inflammation and blood coagulation. Similar SWCNT uptake behavior was found in spleen and kidney, whereas, no obvious pathological changes were observed in these organs.

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Author

Bin Kang; Decai Yu; Yaodong Dai; Shuquan Chang; Da Chen; Yitao Ding

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6223)

Published

2009

Language

EN

Field

Materials Science (Physical Sciences)