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Extensive evaluation of genetic polymorphism of CYP2C19 in a Korean population: interethnic comparison among Asian populations by Lee, J is a Medicine article available to read on EtoBox.
What is Extensive evaluation of genetic polymorphism of CYP2C19 in a Korean population: interethnic comparison among Asian populations about?
We evaluated the frequency distribution of the cytochrome P450 2C19 (CYP2C19) allelic variants in a Korean population and also measured the metabolic ratio of omeprazole, a probe drug for CYP2C19 according to the genotypes. The results were compared with those of other ethnics including Vietnamese data which we had studied. Genotyping of CYP2C19 (\*2 and \*3) was carried out in 282 Korean subjects using PCR-RFLP and ninety-four subjects were participated in phenotyping study using omeprazole. Plasma concentrations of omeprazole and its metabolite, hydroxy-omeprazole were measured at 2hr after 20mg omeprazole intake. Forty subjects were identified to have CYP2C19 genotype of PM with the frequency of 8.9% CYP2C19\*2/\*2, 3.9% CYP2C192/\*3, and 1.4% CYP2C19\*3/ \*3, while 242 Korean subjects carried extensive metabolizer (EM) genotypes which consists of CYP2C19\*1/\*1 (41.8%), CYP2C19\*1/\*2 (35.5%), and CYP2C19\*1/\*3 (8.5%). The frequency distribution of metabolic ratio was distinctly bimodal. Ten Korean subjects were identified to be PMs with an antimode of 1.2. The frequency (12.6 %) of PM in Korean population is significantly higher than those in Vietnamese (7.1 %) and Thai (6.5)
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- Author
- Lee, J
- Publisher
- Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)