Opening book details…
Can I read Magnetic Resonance Imaging of Inflammation with a Specific Selectin-targeted Contrast Agent on EtoBox?
Magnetic Resonance Imaging of Inflammation with a Specific Selectin-targeted Contrast Agent by Sébastien Boutry; Carmen Burtea; Sophie Laurent; Gérard Toubeau; Luce Vander Elst; Robert N. Muller is a Medicine article available to read on EtoBox.
What is Magnetic Resonance Imaging of Inflammation with a Specific Selectin-targeted Contrast Agent about?
## Abstract E‐selectin‐targeted contrast enhancement of blood vessels in inflamed tissues was investigated with a new contrast agent, Gd‐DTPA‐B(sLe^x^)A, which was recently obtained by grafting a synthetic mimetic of sialyl‐Lewis^x^, an E‐selectin ligand, onto Gd‐DTPA. The pharmacokinetics, biodistribution, and potential to image inflammation by MRI of this E‐selectin‐targeted contrast agent were evaluated. The inhibition (by 15–34%) produced by Gd‐DTPA‐B(sLe^x^)A on Sialyl Le^x^‐PAA‐biotin binding to E‐selectin confirmed the specific interaction of the new contrast agent with this adhesion molecule. Gd‐DTPA‐B(sLe^x^)A was tested at a dose of 0.1 mmol/kg b.w. on mice and rats in a fulminant hepatitis model induced by the co‐administration of D‐galactosamine and __E. coli__ lipopolysaccharide. A significant and prolonged contrast enhancement between blood vessels and liver parenchyma was obtained in pathological conditions, which attests to the specificity of the agent for E‐selectin. The prolonged vascular residence (48.9 min in hepatitis vs. 29.8 min in healthy animals), as evidenced by the pharmacokinetic characterization, suggests that Gd‐DTPA‐B(sLe^x^)A interacts with the speci
Who reads Magnetic Resonance Imaging of Inflammation with a Specific Selectin-targeted Contrast Agent?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sébastien Boutry; Carmen Burtea; Sophie Laurent; Gérard Toubeau; Luce Vander Elst; Robert N. Muller
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)