Can I read Methyl 3-amino-3-deoxy-β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-β-d-glucopyranoside: An inhibitor of UDP-d-galactose: β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-d-glucose(1 → 3)-α-d-galactopyranosyltransferase on EtoBox?

Methyl 3-amino-3-deoxy-β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-β-d-glucopyranoside: An inhibitor of UDP-d-galactose: β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-d-glucose(1 → 3)-α-d-galactopyranosyltransferase by Anne-Charlotte Helland; Ole Hindsgaul; Monica M. Palcic; Cheryl L.M. Stults; Bruce A. Macher is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Methyl 3-amino-3-deoxy-β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-β-d-glucopyranoside: An inhibitor of UDP-d-galactose: β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-d-glucose(1 → 3)-α-d-galactopyranosyltransferase about?

UDP-D-galactose:fl-D-galactopyranosyl-(l ~ 4)-2-acetamido-2-deoxy-D-glucose a-(1 ~ 3)-Dgalactopyranosyltransferase [E.C . 2.4.1.151] transfers o-galactosyl-residues from the sugar nucleotide with retention of configuration. We report here that synthetic methyl 3'-amino-3'-deoxy-N-acetyllactosaminide (9), where the hydroxyl group normally undergoing galactosylation has been replaced by amino group, is an inhibitor for this enzyme with K i = 104/xM. The mode of inhibition is not competitive, but appears to be specific, since other glycosyltransferases were not affected by 9.

Who reads Methyl 3-amino-3-deoxy-β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-β-d-glucopyranoside: An inhibitor of UDP-d-galactose: β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-d-glucose(1 → 3)-α-d-galactopyranosyltransferase?

Author

Anne-Charlotte Helland; Ole Hindsgaul; Monica M. Palcic; Cheryl L.M. Stults; Bruce A. Macher

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)