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Distinct Cytogenetic and Clinicopathologic Features in Acute Myeloid Leukemia After Occupational Exposure to Pesticides and Organic Solvents by Franca Fagioli; Antonio Cuneo; Nadia Piva; Maria Gretel Carli; Rita Previati; Massimo Balboni; Paolo Tomasi; Daniele Cariani; Gianluigi Scapoli; Gianluigi Castoldi is a Medicine article available to read on EtoBox.
What is Distinct Cytogenetic and Clinicopathologic Features in Acute Myeloid Leukemia After Occupational Exposure to Pesticides and Organic Solvents about?
Background. To study the correlation of environmental exposure to potentially mutagenic agents and the clinicopathologic picture in acute myeloid leukemia (AML), clinical features, morphologic characteristics, immunophenotype, and cytogenetics were studied in 59 patients with newly diagnosed AML. Methods. Based on interviews on occupational hazards and hobbies showing prolonged contact with pesticides (18 patients) and organic solvents (7 patients), 25 patients were categorized as "exposed." Thirty-four patients were categorized as "unexposed," based on anamnestic findings. Results. Light microscopic studies showed myelodysplasia involving multiple cell lineages in all assessable patients with professional exposure to pesticides and organic solvents, whereas morphologic aberrations of the non-blast cell population were confined to a minority of cells in unexposed patients. These findings were confirmed by electron microscopic studies in 31 patients. Immunologic analysis showed the presence of a minor megakaryoblastic component in six exposed patients and showed positive findings for the CD34 stem cell marker in 85% of exposed patients, a figure significantly higher as compared with
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- Author
- Franca Fagioli; Antonio Cuneo; Nadia Piva; Maria Gretel Carli; Rita Previati; Massimo Balboni; Paolo Tomasi; Daniele Cariani; Gianluigi Scapoli; Gianluigi Castoldi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1992
- Language
- EN
- Field
- Medicine (Health Sciences)