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Comparison between B·R·A·H·M·S PCT direct, a new sensitive point-of-care testing device for rapid quantification of procalcitonin in emergency department patients and established reference methods – a prospective multinational trial by Alexander Kutz; Pierre Hausfater; Michael Oppert; Murat Alan; Eva Grolimund; Claire Gast; Christine Alonso; Christoph Wissmann; Christian Kuehn; Maguy Bernard; Andreas Huber; Beat Mueller; Philipp Schuetz is a Medicine article available to read on EtoBox.

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## Background: Procalcitonin (pct) is increasingly being used for the diagnostic and prognostic work up of patients with suspected infections in the emergency department (ed). recently, b·r·a·h·m·s pct direct, the first high sensitive point-of-care test (poct), has been developed for fast pct measurement on capillary or venous blood samples. ## Methods: This is a prospective, international comparison study conducted in three european eds. consecutive patients with suspicion of bacterial infection were included. duplicate determination of pct was performed in capillary (fingertip) and venous whole blood (edta), and compared to the reference method. the diagnostic accuracy was evaluated by correlation and concordance analyses. ## Results: Three hundred and three patients were included over a 6-month period (60.4% male, median age 65.2 years). the correlation between capillary or venous whole blood and the reference method was excellent: r2=0.96 and 0.97, sensitivity 88.1% and 93.0%, specificity 96.5% and 96.8%, concordance 93% and 95%, respectively at a 0.25 μg/l threshold. no significant bias was observed (-0.04 and -0.02 for capillary and venous whole blood) although there were 6.8

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Author

Alexander Kutz; Pierre Hausfater; Michael Oppert; Murat Alan; Eva Grolimund; Claire Gast; Christine Alonso; Christoph Wissmann; Christian Kuehn; Maguy Bernard; Andreas Huber; Beat Mueller; Philipp Schuetz

Publisher

Walter de Gruyter GmbH

Published

2015

Language

EN

Field

Medicine (Health Sciences)