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This review discusses immune toxicities associated with recombinant adeno-associated virus (rAAV) gene therapy, highlighting serious adverse events observed in clinical trials, such as thrombotic microangiopathy and hepatotoxicity. It emphasizes the role of pre-existing anti-AAV immunity and the need for immunomodulatory strategies to mitigate these toxicities for improved patient outcomes. The document also outlines the mechanisms of immune responses and the importance of clinical care protocols to monitor

Author

spinanatomico

Language

EN