Can I read Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: What is the evidence? on EtoBox?

Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: What is the evidence? by Emmanuel S. Antonarakis; Jamie L. Evans; Gemma F. Heard; Lucy M. Noonan; Barry L. Pizer; Richard D.W. Hain is a Medicine article available to read on EtoBox.

What is Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: What is the evidence? about?

## Abstract ## Background Nausea and vomiting are preventable side effects of cancer chemotherapy for children. Antiemetics are essential, especially as treatment becomes more intensive. Many drugs are available, but adequate evidence‐based recommendations are lacking. We aimed (1) to consider an evidence‐based approach for pharmacological prophylaxis of chemotherapy‐induced nausea and vomiting (CINV) in children, and (2) to compare this approach with antiemetic prescribing in two paediatric oncology centres. ## Procedure Relevant publications (Medline, Embase, CancerLit:1966–2002) were critically evaluated using pre‐defined criteria. Evidence‐based statements summarising their findings were formulated, and evidence basis proposed. Current prescribing practice was then compared with this evidence basis in Welsh children under 16 receiving chemotherapy at Llandough Hospital, Cardiff or Alder Hey Children's Hospital, Liverpool between 1 January 2001 and 31 December 2001. ## Results Of 213 studies retrieved, 82 provided evidence. Our evidence basis recommends combination 5HT~3~‐antagonist/corticosteroid for highly emetogenic chemotherapy, 5HT~3~‐antagonist alone for moderate emetogeni

Who reads Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: What is the evidence??

Author

Emmanuel S. Antonarakis; Jamie L. Evans; Gemma F. Heard; Lucy M. Noonan; Barry L. Pizer; Richard D.W. Hain

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2004

Language

EN

Field

Medicine (Health Sciences)