Can I read Perinatal supplementation of low doses of ethanol enhances 5-HT restoration in the central nervous system on EtoBox?

Perinatal supplementation of low doses of ethanol enhances 5-HT restoration in the central nervous system by Elena Germani; Martha Lilia Tena Suck; Anna Maria Di Giulio; Alfredo Gorio is a Neuroscience article available to read on EtoBox.

What is Perinatal supplementation of low doses of ethanol enhances 5-HT restoration in the central nervous system about?

It has been reported that long-term administration of ethanol has deleterious effects on the central nervous system; the alterations are particularly evident if the exposure occurs during development. Our study shows that rat perinatal administration of 3% and 6% ethanol does not alter development of serotonin (5-HT) pathways in the central nervous system, while their reactive changes triggered by neonatal lesioning are greatly altered. The administration of 5,7-dihydroxytriptamine (5,7-DHT) within 6 hours from birth causes 5-HT fiber degeneration throughout the central nervous system. The loss of 5-HT is particularly relevant in lumbar spinal cord, occipital cortex, and hippocampus. This early decrease in 5-HT content is followed by a slow and partial recovery. If animals are exposed to 3% ethanol during the perinatal period, there is an enhancement of the 5,7-DHT-induced degeneration that is, however, followed by a faster and greater recovery throughout the central nervous system. Conversely, perinatal exposure to 6% ethanol and 5,7-DHT administration lead to an irreversible 5-HT loss with no subsequent recovery. The deleterious effects of 6% ethanol are accompanied by a reduced

Who reads Perinatal supplementation of low doses of ethanol enhances 5-HT restoration in the central nervous system?

Author

Elena Germani; Martha Lilia Tena Suck; Anna Maria Di Giulio; Alfredo Gorio

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1999

Language

EN

Field

Neuroscience (Life Sciences)