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Impact of mesangial IgA deposits in 14th-post operative-day routine renal allograft biopsies by Yong-Soo Kim; Young Jin Choi; Bum Soon Choi; Joo Hyun Park; Chul Woo Yang; Suk Young Kim; Byung Kee Bang is a Medicine article available to read on EtoBox.
What is Impact of mesangial IgA deposits in 14th-post operative-day routine renal allograft biopsies about?
**__SUMMARY:__** Three hundred fourteen 14th‐postoperative‐day routine renal allograft biopsies were evaluated together with clinical data. Out of 314 biopsies, mesangial IgA deposits were positive in 122 biopsies (39%). According to Banff classification, the rate of acute rejection was significantly lower in mesangial IgA deposit‐positive (IgA(+)) patients (7.4%) than in mesangial IgA deposit‐negative (IgA(‐)) patients (19.7%) on the 14th postoperative day. Thereafter, rate of biopsy‐proven and clinical acute rejection was continuously lower for up to 12 months in IgA(+) patients than in IgA(‐) patients. The detection rate of mesangial IgA deposits was significantly higher in human leucocyte antigen (HLA)‐well‐matched (HLA mismatch number was <3) patients than in HLA‐poorly matched (HLA mismatch number was ≥3) patients. In HLA‐well‐matched patients, the serum creatinine levels were significantly lower in IgA(+) patients than in IgA(‐) patients after 3 post‐transplant months and up to 1 post‐transplant year. Follow‐up (mean interval: 13 months) allograft biopsies were performed in 34 patients out of 122 IgA(+) patients. In the follow‐up biopsies, initially detected mesangial IgA de
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- Author
- Yong-Soo Kim; Young Jin Choi; Bum Soon Choi; Joo Hyun Park; Chul Woo Yang; Suk Young Kim; Byung Kee Bang
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1320-5358)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)