Can I read 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels on EtoBox?

4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels by Arvie Abiero; Chrislean Jun Botanas; Raly James Custodio; Leandro Val Sayson; Mikyung Kim; Hyun Jun Lee; Hee Jin Kim; Kun Won Lee; Youngdo Jeong; Joung-Wook Seo; In Soo Ryu; Yong Sup Lee; Jae Hoon Cheong is a Neuroscience article available to read on EtoBox.

What is 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels about?

## Rationale: A high number of synthetic dissociative drugs continue to be available through online stores, leading to their misuse. recent inclusions in this category are 4-meo-pcp and 3-meo-pcmo, analogs of phencyclidine. although the dissociative effects of these drugs and their recreational use have been reported, no studies have investigated their abuse potential. ## Objectives: To examine their rewarding and reinforcing effects and explore the mechanistic correlations. ## Methods: We used conditioned place preference (cpp), self-administration, and locomotor sensitization tests to assess the rewarding and reinforcing effects of the drugs. we explored their mechanism of action by pretreating dopamine receptor (dr) d1 antagonist sch23390 and drd2 antagonist haloperidol during cpp test and investigated the effects of 4-meo-pcp and 3-meo-pcmo on dopamine-related proteins in the ventral tegmental area and nucleus accumbens. we also measured the levels of dopamine, phosphorylated cyclic-amp response element-binding (p-creb) protein, deltafosb, and brain-derived neurotrophic factor (bdnf) in the nucleus accumbens. additionally, we examined the effects of both drugs on brain wave act

Who reads 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels?

Author

Arvie Abiero; Chrislean Jun Botanas; Raly James Custodio; Leandro Val Sayson; Mikyung Kim; Hyun Jun Lee; Hee Jin Kim; Kun Won Lee; Youngdo Jeong; Joung-Wook Seo; In Soo Ryu; Yong Sup Lee; Jae Hoon Cheong

Publisher

Springer Science and Business Media LLC

Published

2019

Language

EN

Field

Neuroscience (Life Sciences)