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This Perspective discusses the role of biological clocks in maintaining mitotic fidelity, emphasizing the importance of accurate chromosome segregation for organismal development and the prevention of tumorigenesis. It highlights recent advances in understanding mitotic timing mechanisms, including the apoptotic timer, minimum duration of mitosis clock, and mitotic-stopwatch pathway, which help cells detect and respond to mitotic errors. The authors propose a conceptual framework for how cells integrate tem

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pevive4944

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EN