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Clozapine, the first second-generation antipsychotic discovered in 1958, is primarily used for treatment-resistant schizophrenia and has a unique mechanism of action that reduces extrapyramidal symptoms. It undergoes extensive metabolism in the liver and gut, with a half-life of 12 hours, requiring careful dosage management and monitoring due to potential severe side effects like agranulocytosis and seizures. Contraindications include hypersensitivity, low white blood cell counts, and previous bone marrow d
- Author
- kspks46syari
- Language
- EN