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203 Heightened levels of microvesicle particles resulting from combination of ethanol and thermal burn injury by C. Brewer; A.a. Awoyemi; C. Rapp; C.E. Borchers; J.B. Travers is a Medicine article available to read on EtoBox.

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Sarecycline (SAR) is a tetracycline-class antibiotic FDA-approved for treatment of moderateto-severe acne. In vitro studies demonstrated a narrow-spectrum antibacterial activity, targeting clinically relevant Gram-positive bacteria with reduced activity against Gram-negative bacteria commonly found in the human gastrointestinal tract. A murine systemic (intraperitoneal) infection model was used to assess the in vivo efficacies of SAR, doxycycline (DOX), and minocycline (MIN) against S. aureus and E. coli. At 48 hours after systemic infection with S. aureus, SAR, DOX, and MIN had a protective dose required to achieve 50% survival (PD 50 ) of 0.25, 0.3, and 0.03 mg/kg, respectively. In contrast, SAR did not demonstrate in vivo efficacy against E. coli even at the highest dose (PD 50 >40 mg/kg), while DOX and MIN had a PD 50 of 5.72 and 6.95 mg/kg, respectively. A murine neutropenic thigh wound infection model was used to model tissue-based infection to assess efficacies of SAR and DOX against S. aureus. At 24 hours post infection, SAR achieved a 2-log 10 reduction of thigh bacterial burden comparable to DOX, with 50% effective dose (ED 50 ) values of 8.23 and 8.32mg/kg, respectively.

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Author

C. Brewer; A.a. Awoyemi; C. Rapp; C.E. Borchers; J.B. Travers

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)