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Cancer Risk After Radioactive Iodine Treatment for Hyperthyroidism: A Cohort Study by Naomi Gronich; Idit Lavi; Gad Rennert; Walid Saliba is a Medicine article available to read on EtoBox.

What is Cancer Risk After Radioactive Iodine Treatment for Hyperthyroidism: A Cohort Study about?

Radioactive iodine (I) is in widespread use for the treatment of hyperthyroidism. Data on long-term safety outcome are limited and conflicting. The objectives of this study were to evaluate the association of radioiodine treatment for hyperthyroidism with overall cancer and with specific cancer types. This is a historical cohort study, using the Clalit health care database. Participants were all adults with a new diagnosis of hyperthyroidism in 2002-2015, newly treated with I, or with thionamides (propylthiouracil/thiamazole), excluding patients with previous malignancies. Age, sex, smoking history, body mass index, Clalit district, socioeconomic status, history of diabetes mellitus and of hypertension, use of aspirin and of statins, and adherence to cancer screening procedures were used to calculate propensity score to receive radioiodine. Incidence rates and 95% confidence intervals (CIs) were calculated for overall cancer occurrence, and for each cancer type using Poisson distribution. Association between study variables and time to cancer event was evaluated using cause-specific hazard ratios (HR) and CIs, estimated by univariate and propensity score adjusted multivariate Cox p

Who reads Cancer Risk After Radioactive Iodine Treatment for Hyperthyroidism: A Cohort Study?

Author

Naomi Gronich; Idit Lavi; Gad Rennert; Walid Saliba

Publisher

Mary Ann Liebert; Mary Ann Liebert Inc.; Mary Ann Liebert Inc (ISSN 1050-7256)

Published

2019

Language

EN

Field

Medicine (Health Sciences)