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Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas by Keisuke Kurose; Nobuya Mine; Aritoshi Iida; Hisaki Nagai; Haruhito Harada; Tsutomu Araki; Mitsuru Emi is a Medicine article available to read on EtoBox.

What is Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas about?

Cytogenetic aberrations involving chromosome region 12q13-15 occur frequently among benign mesenchymal tumors in humans, e.g., pleomorphic adenomas of the parotid gland, pulmonary chondroid hamartomas, lipomas, or uterine leiomyomas. HMGIC, a gene encoding a protein of the high-mobility group, has been identified as a target of those events. Using the 3Ј rapid amplification of cDNA ends (RACE) technique, we identified six different fusion transcripts of the HMGIC gene among 13 uterine leiomyomas; three of these variants had not been described before. Radiation-hybrid mapping located all three of the novel fusion transcripts in the same chromosomal region as the HMGIC gene. Cloning of the entire HMGIC gene in a genomic contig of P1-derived artificial chromosomes and cosmids revealed that the 3Ј portion of each novel fusion transcript contained cryptic exonic sequences (designated a, b, and c) present in intron 3 of the HMGIC gene. Thus, aberrant alternative splicing was responsible for abnormal HMGIC isoforms in those myomas. Identification of these novel variants suggested that aberrant splicing can join chromosomal translocation and inversion as a mechanism for producing abnormal

Who reads Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas?

Author

Keisuke Kurose; Nobuya Mine; Aritoshi Iida; Hisaki Nagai; Haruhito Harada; Tsutomu Araki; Mitsuru Emi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2001

Language

EN

Field

Medicine (Life Sciences)