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The Mechanism of Pkcb-P66Shc-Nadph Oxidase Pathway in High Glucose Induced-Oxidative Stress in Renal Tubular Epithelial Cells by YS Cheng; J Chao; DD Zhu; BC Liu is a Medicine article available to read on EtoBox.

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Background Panax notoginseng saponins (PNS), the main active ingredient extracted from the Chinese herb SanQi, has antiapoptotic, antioxidant, and anti-inflammatory effects to protect the heart from myocardial ischemia/reperfusion injury (MIRI). ATP-sensitive potassium (K ATP ) channel plays an important role in pharmacological preconditioning against MIRI. However, its effect on inflammation induced by MIRI remains elusive. Thus, we hypothesise that PNS alleviates the inflammatory response induced by MIRI, and K ATP channels play a crucial role in it. Methods The rat MIRI model was established by 40 min left anterior descending coronary artery occlusion followed by 60 min reperfusion. PNS was administered 30 min before ischemia, glibenclamide was administered 10 min before PNS. Cardiac function, myocardial histology, and MPO activity were evaluated. The levels of inflammatory mediators TNF-a and MCP-1 in myocardium were measured by ELISA. The protein and gene expression of K ATP channel subunits were determined by Western blot analysis and real-time PCR. Results PNS pretreatment ameliorated cardiac function and myocardial pathological changes, decreased myocardial MPO activity and

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Author

YS Cheng; J Chao; DD Zhu; BC Liu

Publisher

SAGE Publications

Published

2017

Language

EN

Field

Medicine (Health Sciences)