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Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor by Nino Porakishvili; Ketki Vispute; Andrew J. Steele; Nadeeka Rajakaruna; Nina Kulikova; Tamar Tsertsvadze; Amit Nathwani; Rajendra N. Damle; Edward A. Clark; Kanti R. Rai; Nicholas Chiorazzi; Peter M. Lydyard is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor about?

Chronic lymphocytic leukemia (CLL) development and progression are thought to be driven by unknown antigens/autoantigens through the B cell receptor (BCR) and environmental signals for survival and expansion including toll-like receptor (TLR) ligands. CD180/RP105, a membrane-associated orphan receptor of the TLR family, induces normal B cell activation and proliferation and is expressed by approximately 60% of CLL samples. Half of these respond to ligation with anti-CD180 antibody by increased activation/phosphorylation of protein kinases associated with BCR signaling. Hence CLL cells expressing both CD180 and the BCR could receive signals via both receptors. Here we investigated cross-talk between BCR and CD180-mediated signaling on CLL cell survival and apoptosis. Our data indicate that ligation of CD180 on responsive CLL cells leads to activation of either prosurvival Bruton tyrosine kinase (BTK)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT-mediated, or proapoptotic p38 mitogen-activated protein kinase (p38MAPK)-mediated signaling pathways, while selective immunoglobulin M (sIgM) ligation predominantly engages the BTK/PI3K/AKT pathway. Furthermore, pretreatment of C

Who reads Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor?

Author

Nino Porakishvili; Ketki Vispute; Andrew J. Steele; Nadeeka Rajakaruna; Nina Kulikova; Tamar Tsertsvadze; Amit Nathwani; Rajendra N. Damle; Edward A. Clark; Kanti R. Rai; Nicholas Chiorazzi; Peter M. Lydyard

Publisher

The Feinstein Institute for Medical Research; Springer (Biomed Central Ltd.); North Shore - Long Jewish Research Institute; Baltimore Md.: Johns Hopkins University Press; Manhasset NY: North Shore-Long Island Jewish Research Institute; Manhasset NY: Feinstein Institute for Medical Research; [London]: BioMed Central; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Test accounts (ISSN 1076-1551)

Published

2015

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)